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| Deleterious | harmful |
| Deliberate | to think over deeply |
| Delineation | demarcation; explanation; definition; outlining |
| Demur | hesitate; refuse |
| Denounce | condemn; speak out against |
| Deplete | use up; lessen |
| Deplore | regret |
| Depravity | moral corruption |
| Deprecate | criticize; denounce |
| Deride | ridicule; make fun of; mock |
| Derogatory | uncomplimentary |
| Desecrate | to damage or pollute a holy place |
| Desecration | spoiling something holy |
| Desist | stop; discontinue; cease |
| Despondent | having no hope; miserable |
| Destitution | hardship; poverty; misery |
| Deter | put off; prevent |
| Deteriorate | worsen; decline |
| Detrimental | harmful |
| Devoured | greedily eaten/consumed |