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| Unequivocal | clear; obvious |
| Unfetter | set free |
| Unfrock | to remove a priest from his position |
| Unprecedented | never having happened before |
| Unscathed | unharmed; intact; without a scratch |
| Unwitting | not deliberate; unconscious |
| Upbraid | scold; tell off; reprimand |
| Uproarious | hilarious; hysterical; very funny |
| Upshot | outcome |
| Urbane | sophisticated; suave |
| Usurp | take someone's position (usually by force) |
| Utilitarian | useful |
| Utopian | a believer in an ideal world |
| Vacillate | waver; hesitate |
| Vacuous | empty; silly; meaningless |
| Vagrant | person wandering without a home |
| Vapid | dull; uninspiring |
| Variegated | multicolored; speckled |
| Vehemence | violence; fervor; forcefulness |
| Vehement | forceful |